ackground : We studied the prevalence of Hepatits C viruses in various liver disease in Korea using recombinant viral antigen (C 100-3) to evaluate its etiological significance and routes of transmission.
Methods : A total of 256 patients with chronic renal failure who experienced transfusion or
hepatocellular disease were tested for serum HBsAg & Ab, HBsAb, Anti-HCV, AST, ALT
and some were performed liver biosy for diagnostic purpose. The 46 cases of acute hepatitis,
78 cases of chronic hepatits, 25 cases of liver cirrhosis, 30 cases of hepatocellular carcinoma,
15 cases of hemodyalysis patients, 62 cases of hepatitis B virus carrier were studied.
Results :
1) There were 1.2% Anti-HCV positive patients among 256 cases. Among them there
were 32.0% of liver cirrhosis, 16.7% of hepatocellular carcinoma, 20.0% of hemodialysis
patients, 8.7% of acute hepatitis, 11.5% of chronic hepatitis, 4.8% of hepatitis B virus csrrier
(Table 1).
2) Among 184 cases of HBsAg positive patient, 20 cases (10.9%) were Anti-HCV positive
and among 72 cases of HBsAg negative patients, 12 cases (16.7%) were Anti-HCV positive
(Table 2, 3).
3) Among 32 cases of Anti-HCV positive patients, 20 cases (62.5%) were HBsAg positive
and 12 cases were negative (Table 4).
4) Among Anti-HCV positive and HBsAg negative patients, the higher positive response
of Anti-HCV were noted in patients with HBcAb positive and increased AST and ALT
(Table 5).
5) Among Anti-HCV positive patients, the 65.4% were related to transfusion or
acupuncture (Table 6).
Conclision : This study shows that further research for the development of more sensitive
and specific diagnodtic method for hepatitis C and thorough follow up study for its routes of
transmission are needed.
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